Some UVM Bioinformatics Core Services in Pictures

Mapping sequence properties onto structure.

Walker DR, Bond JP, Tarone RE, Harris CC, Makalowski W, Boguski MS, Greenblatt MS. Evolutionary conservation and somatic mutation hotspot  maps of p53: correlation with p53 protein structural and functional features. Oncogene. 1999 Jan 7;18(1):211-8.

Mapping electrostatic potential onto a molecular surface

Walter NG, Yang N, Burke JM. Probing non-selective cation binding in the hairpin ribozyme with Tb(III).

J Mol Biol. 2000 May 5;298(3):539-55.

Phylogenetic analysis

Wallace SS, Bandaru V, Kathe SD, Bond JP. The enigma of endonuclease VIII. DNA Repair (Amst). 2003 May 13;2(5):441-53. No abstract available.

Bandaru V, Sunkara S, Wallace SS, Bond JP.A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII. DNA Repair (Amst). 2002 Jul 17;1(7):517-29.

Homology Modeling

Wallace, S.S. and Bond, J.P. A homology model of hOGG1.  presented at the 1999 meeting on DNA Repair and Mutagenasis: Mechanism, Control, and Biological Consequences prior to the presentation of the experimentally determined structure by Greg Verdine (see Bruner SD, Norman DP, Verdine GL. ) .

Microarray data analysis

Bioinformatics Education

Bond, JP Navigating NCBI Resources, Presented at the BioQuest BEDROCK workshop at UVM.

UVM BioDesktop

The UVM BioDesktop can be used for management and analysis of sequences, structures, alignments and trees.   

Custom data analysis

H. Bond and L. Markowitz, A major result.  I would want to think about this one before reading the explanation.